Emerin Represses STAT3 Signaling through Nuclear Membrane-Based Spatial Control

Emerin is the inner nuclear membrane protein involved in maintaining mechanical integrity of membrane. Mutations EMD encoding emerin cause Emery–Dreifuss muscular dystrophy (EDMD). Evidence accumulating that regulation specific gene expression associated with this disease, but exact function has not been fully elucidated. Here, we show downregulates Signal transducer and activators transcription 3 (STAT3) signaling, activated exclusively by Janus kinase (JAK). Deletion mutation experiments lamin-binding domain essential for inhibition STAT3 signaling. interacts directly co-localizes knockdown induces target genes Bcl2 Survivin to increase cell survival signals suppress hydrogen peroxide-induced death HeLa cells. Specifically, downregulation BAF or lamin A/C increases suggesting correct-localized emerin, assembling A/C, acts as an intrinsic inhibitor against In C2C12 cells, gene, Pax7, abnormal myoblast proliferation muscle wasting skeletal homeostasis. Our results indicate signaling inducing retention delaying This mechanism provides clues etiology emerin-related may be a new therapeutic treatment.